Pesquisa | Biblioteca Virtual em Saúde Fiocruz

1.

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.

Replogle, Joseph M; Saunders, Reuben A; Pogson, Angela N; Hussmann, Jeffrey A; Lenail, Alexander; Guna, Alina; Mascibroda, Lauren; Wagner, Eric J; Adelman, Karen; Lithwick-Yanai, Gila; Iremadze, Nika; Oberstrass, Florian; Lipson, Doron; Bonnar, Jessica L; Jost, Marco; Norman, Thomas M; Weissman, Jonathan S.

Cell ; 185(14): 2559-2575.e28, 2022 07 07.

Artigo em Inglês | MEDLINE | ID: mdl-35688146

2.

The Roots of Genetic Coding in Aminoacyl-tRNA Synthetase Duality.

Carter, Charles W; Wills, Peter R.

Annu Rev Biochem ; 90: 349-373, 2021 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-33781075

3.

Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic.

Jackson, Ben; Boni, Maciej F; Bull, Matthew J; Colleran, Amy; Colquhoun, Rachel M; Darby, Alistair C; Haldenby, Sam; Hill, Verity; Lucaci, Anita; McCrone, John T; Nicholls, Samuel M; O'Toole, Áine; Pacchiarini, Nicole; Poplawski, Radoslaw; Scher, Emily; Todd, Flora; Webster, Hermione J; Whitehead, Mark; Wierzbicki, Claudia; Loman, Nicholas J; Connor, Thomas R; Robertson, David L; Pybus, Oliver G; Rambaut, Andrew.

Cell ; 184(20): 5179-5188.e8, 2021 09 30.

Artigo em Inglês | MEDLINE | ID: mdl-34499854

4.

Data Sanitization to Reduce Private Information Leakage from Functional Genomics.

Gürsoy, Gamze; Emani, Prashant; Brannon, Charlotte M; Jolanki, Otto A; Harmanci, Arif; Strattan, J Seth; Cherry, J Michael; Miranker, Andrew D; Gerstein, Mark.

Cell ; 183(4): 905-917.e16, 2020 11 12.

Artigo em Inglês | MEDLINE | ID: mdl-33186529

5.

Major Impacts of Widespread Structural Variation on Gene Expression and Crop Improvement in Tomato.

Alonge, Michael; Wang, Xingang; Benoit, Matthias; Soyk, Sebastian; Pereira, Lara; Zhang, Lei; Suresh, Hamsini; Ramakrishnan, Srividya; Maumus, Florian; Ciren, Danielle; Levy, Yuval; Harel, Tom Hai; Shalev-Schlosser, Gili; Amsellem, Ziva; Razifard, Hamid; Caicedo, Ana L; Tieman, Denise M; Klee, Harry; Kirsche, Melanie; Aganezov, Sergey; Ranallo-Benavidez, T Rhyker; Lemmon, Zachary H; Kim, Jennifer; Robitaille, Gina; Kramer, Melissa; Goodwin, Sara; McCombie, W Richard; Hutton, Samuel; Van Eck, Joyce; Gillis, Jesse; Eshed, Yuval; Sedlazeck, Fritz J; van der Knaap, Esther; Schatz, Michael C; Lippman, Zachary B.

Cell ; 182(1): 145-161.e23, 2020 07 09.

Artigo em Inglês | MEDLINE | ID: mdl-32553272

6.

An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.

Kawasaki, Kenta; Toshimitsu, Kohta; Matano, Mami; Fujita, Masashi; Fujii, Masayuki; Togasaki, Kazuhiro; Ebisudani, Toshiki; Shimokawa, Mariko; Takano, Ai; Takahashi, Sirirat; Ohta, Yuki; Nanki, Kosaku; Igarashi, Ryo; Ishimaru, Kazuhiro; Ishida, Hiroki; Sukawa, Yasutaka; Sugimoto, Shinya; Saito, Yoshimasa; Maejima, Kazuhiro; Sasagawa, Shota; Lee, Hwajin; Kim, Hong-Gee; Ha, Kyungsik; Hamamoto, Junko; Fukunaga, Koichi; Maekawa, Aya; Tanabe, Minoru; Ishihara, Soichiro; Hamamoto, Yasuo; Yasuda, Hiroyuki; Sekine, Shigeki; Kudo, Atsushi; Kitagawa, Yuko; Kanai, Takanori; Nakagawa, Hidewaki; Sato, Toshiro.

Cell ; 183(5): 1420-1435.e21, 2020 11 25.

Artigo em Inglês | MEDLINE | ID: mdl-33159857

7.

Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos.

Zuccaro, Michael V; Xu, Jia; Mitchell, Carl; Marin, Diego; Zimmerman, Raymond; Rana, Bhavini; Weinstein, Everett; King, Rebeca T; Palmerola, Katherine L; Smith, Morgan E; Tsang, Stephen H; Goland, Robin; Jasin, Maria; Lobo, Rogerio; Treff, Nathan; Egli, Dieter.

Cell ; 183(6): 1650-1664.e15, 2020 12 10.

Artigo em Inglês | MEDLINE | ID: mdl-33125898

8.

Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals.

Romanov, Natalie; Kuhn, Michael; Aebersold, Ruedi; Ori, Alessandro; Beck, Martin; Bork, Peer.

Cell ; 177(5): 1308-1318.e10, 2019 05 16.

Artigo em Inglês | MEDLINE | ID: mdl-31031010

9.

Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore.

Wu, Degang; Dou, Jinzhuang; Chai, Xiaoran; Bellis, Claire; Wilm, Andreas; Shih, Chih Chuan; Soon, Wendy Wei Jia; Bertin, Nicolas; Lin, Clarabelle Bitong; Khor, Chiea Chuen; DeGiorgio, Michael; Cheng, Shanshan; Bao, Li; Karnani, Neerja; Hwang, William Ying Khee; Davila, Sonia; Tan, Patrick; Shabbir, Asim; Moh, Angela; Tan, Eng-King; Foo, Jia Nee; Goh, Liuh Ling; Leong, Khai Pang; Foo, Roger S Y; Lam, Carolyn Su Ping; Richards, Arthur Mark; Cheng, Ching-Yu; Aung, Tin; Wong, Tien Yin; Ng, Huck Hui; Liu, Jianjun; Wang, Chaolong.

Cell ; 179(3): 736-749.e15, 2019 10 17.

Artigo em Inglês | MEDLINE | ID: mdl-31626772

10.

Global Genetic Networks and the Genotype-to-Phenotype Relationship.

Costanzo, Michael; Kuzmin, Elena; van Leeuwen, Jolanda; Mair, Barbara; Moffat, Jason; Boone, Charles; Andrews, Brenda.

Cell ; 177(1): 85-100, 2019 03 21.

Artigo em Inglês | MEDLINE | ID: mdl-30901552

11.

Combinatorial Genetics Reveals a Scaling Law for the Effects of Mutations on Splicing.

Baeza-Centurion, Pablo; Miñana, Belén; Schmiedel, Jörn M; Valcárcel, Juan; Lehner, Ben.

Cell ; 176(3): 549-563.e23, 2019 01 24.

Artigo em Inglês | MEDLINE | ID: mdl-30661752

12.

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing.

Laks, Emma; McPherson, Andrew; Zahn, Hans; Lai, Daniel; Steif, Adi; Brimhall, Jazmine; Biele, Justina; Wang, Beixi; Masud, Tehmina; Ting, Jerome; Grewal, Diljot; Nielsen, Cydney; Leung, Samantha; Bojilova, Viktoria; Smith, Maia; Golovko, Oleg; Poon, Steven; Eirew, Peter; Kabeer, Farhia; Ruiz de Algara, Teresa; Lee, So Ra; Taghiyar, M Jafar; Huebner, Curtis; Ngo, Jessica; Chan, Tim; Vatrt-Watts, Spencer; Walters, Pascale; Abrar, Nafis; Chan, Sophia; Wiens, Matt; Martin, Lauren; Scott, R Wilder; Underhill, T Michael; Chavez, Elizabeth; Steidl, Christian; Da Costa, Daniel; Ma, Yussanne; Coope, Robin J N; Corbett, Richard; Pleasance, Stephen; Moore, Richard; Mungall, Andrew J; Mar, Colin; Cafferty, Fergus; Gelmon, Karen; Chia, Stephen; Marra, Marco A; Hansen, Carl; Shah, Sohrab P; Aparicio, Samuel.

Cell ; 179(5): 1207-1221.e22, 2019 Nov 14.

Artigo em Inglês | MEDLINE | ID: mdl-31730858

13.

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.

van Galen, Peter; Hovestadt, Volker; Wadsworth Ii, Marc H; Hughes, Travis K; Griffin, Gabriel K; Battaglia, Sofia; Verga, Julia A; Stephansky, Jason; Pastika, Timothy J; Lombardi Story, Jennifer; Pinkus, Geraldine S; Pozdnyakova, Olga; Galinsky, Ilene; Stone, Richard M; Graubert, Timothy A; Shalek, Alex K; Aster, Jon C; Lane, Andrew A; Bernstein, Bradley E.

Cell ; 176(6): 1265-1281.e24, 2019 03 07.

Artigo em Inglês | MEDLINE | ID: mdl-30827681

14.

Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage.

Stanway, Rebecca R; Bushell, Ellen; Chiappino-Pepe, Anush; Roques, Magali; Sanderson, Theo; Franke-Fayard, Blandine; Caldelari, Reto; Golomingi, Murielle; Nyonda, Mary; Pandey, Vikash; Schwach, Frank; Chevalley, Séverine; Ramesar, Jai; Metcalf, Tom; Herd, Colin; Burda, Paul-Christian; Rayner, Julian C; Soldati-Favre, Dominique; Janse, Chris J; Hatzimanikatis, Vassily; Billker, Oliver; Heussler, Volker T.

Cell ; 179(5): 1112-1128.e26, 2019 11 14.

Artigo em Inglês | MEDLINE | ID: mdl-31730853

15.

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.

Lotta, Luca A; Mokrosinski, Jacek; Mendes de Oliveira, Edson; Li, Chen; Sharp, Stephen J; Luan, Jian'an; Brouwers, Bas; Ayinampudi, Vikram; Bowker, Nicholas; Kerrison, Nicola; Kaimakis, Vasileios; Hoult, Diana; Stewart, Isobel D; Wheeler, Eleanor; Day, Felix R; Perry, John R B; Langenberg, Claudia; Wareham, Nicholas J; Farooqi, I Sadaf.

Cell ; 177(3): 597-607.e9, 2019 04 18.

Artigo em Inglês | MEDLINE | ID: mdl-31002796

16.

An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer's brains.

Millet, Alon; Ledo, Jose Henrique; Tavazoie, Sohail F.

Immunity ; 57(1): 153-170.e6, 2024 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-38159571

17.

Disease Heritability Inferred from Familial Relationships Reported in Medical Records.

Polubriaginof, Fernanda C G; Vanguri, Rami; Quinnies, Kayla; Belbin, Gillian M; Yahi, Alexandre; Salmasian, Hojjat; Lorberbaum, Tal; Nwankwo, Victor; Li, Li; Shervey, Mark M; Glowe, Patricia; Ionita-Laza, Iuliana; Simmerling, Mary; Hripcsak, George; Bakken, Suzanne; Goldstein, David; Kiryluk, Krzysztof; Kenny, Eimear E; Dudley, Joel; Vawdrey, David K; Tatonetti, Nicholas P.

Cell ; 173(7): 1692-1704.e11, 2018 06 14.

Artigo em Inglês | MEDLINE | ID: mdl-29779949

18.

Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression.

Schmiedel, Benjamin J; Singh, Divya; Madrigal, Ariel; Valdovino-Gonzalez, Alan G; White, Brandie M; Zapardiel-Gonzalo, Jose; Ha, Brendan; Altay, Gokmen; Greenbaum, Jason A; McVicker, Graham; Seumois, Grégory; Rao, Anjana; Kronenberg, Mitchell; Peters, Bjoern; Vijayanand, Pandurangan.

Cell ; 175(6): 1701-1715.e16, 2018 11 29.

Artigo em Inglês | MEDLINE | ID: mdl-30449622

19.

Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity.

Ding, Yuli; Sun, Tongjun; Ao, Kevin; Peng, Yujun; Zhang, Yaxi; Li, Xin; Zhang, Yuelin.

Cell ; 173(6): 1454-1467.e15, 2018 05 31.

Artigo em Inglês | MEDLINE | ID: mdl-29656896

20.

Pathogenic Germline Variants in 10,389 Adult Cancers.

Huang, Kuan-Lin; Mashl, R Jay; Wu, Yige; Ritter, Deborah I; Wang, Jiayin; Oh, Clara; Paczkowska, Marta; Reynolds, Sheila; Wyczalkowski, Matthew A; Oak, Ninad; Scott, Adam D; Krassowski, Michal; Cherniack, Andrew D; Houlahan, Kathleen E; Jayasinghe, Reyka; Wang, Liang-Bo; Zhou, Daniel Cui; Liu, Di; Cao, Song; Kim, Young Won; Koire, Amanda; McMichael, Joshua F; Hucthagowder, Vishwanathan; Kim, Tae-Beom; Hahn, Abigail; Wang, Chen; McLellan, Michael D; Al-Mulla, Fahd; Johnson, Kimberly J; Lichtarge, Olivier; Boutros, Paul C; Raphael, Benjamin; Lazar, Alexander J; Zhang, Wei; Wendl, Michael C; Govindan, Ramaswamy; Jain, Sanjay; Wheeler, David; Kulkarni, Shashikant; Dipersio, John F; Reimand, Jüri; Meric-Bernstam, Funda; Chen, Ken; Shmulevich, Ilya; Plon, Sharon E; Chen, Feng; Ding, Li.

Cell ; 173(2): 355-370.e14, 2018 04 05.

Artigo em Inglês | MEDLINE | ID: mdl-29625052

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